Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein
The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2015
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf http://eprints.usm.my/45074/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, |
|---|