Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein
Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins a...
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2017
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my.usm.eprints.45399 http://eprints.usm.my/45399/ Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein Kong, Mei Suen RS1-441 Pharmacy and materia medica Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown. 2017-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf Kong, Mei Suen (2017) Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein. PhD thesis, Universiti Sains Malaysia. |
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RS1-441 Pharmacy and materia medica |
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RS1-441 Pharmacy and materia medica Kong, Mei Suen Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| description |
Antigen recognition by T cell receptor (TCR) induces intracellular signaling cascades leading to T cell activation, subsequently inducing cellular proliferation and various effector functions. Adaptor proteins play important roles in T cell signaling by creating nodes to recruit signaling proteins and form signal complexes to regulate the direction of signaling. Casitas B-lineage lymphoma (Cbl)-interacting protein of 85 kDa (CIN85) is an adaptor protein, originally identified as a Cbl-binding protein, and was suggested to be involved in the internalization and degradation of receptors and kinases. Nevertheless, the physiological function of CIN85 in T cells is unknown. |
| format |
Thesis |
| author |
Kong, Mei Suen |
| author_facet |
Kong, Mei Suen |
| author_sort |
Kong, Mei Suen |
| title |
Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_short |
Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_full |
Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_fullStr |
Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_full_unstemmed |
Negative Regulation Of T Cell Activation And Function By CIN85 Adaptor Protein |
| title_sort |
negative regulation of t cell activation and function by cin85 adaptor protein |
| publishDate |
2017 |
| url |
http://eprints.usm.my/45399/1/KONG%20MEI%20SUEN.pdf http://eprints.usm.my/45399/ |
| _version_ |
1646011341142491136 |