Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_

The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopoly...

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Main Author: Wong, Wai Yee
Format: Thesis
Language:English
Published: 2017
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Online Access:http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf
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spelling my.usm.eprints.46566 http://eprints.usm.my/46566/ Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_ Wong, Wai Yee T Technology TA401-492 Materials of engineering and construction. Mechanics of materials The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopolymer coating. Optimum macro- and microporosity in β-TCP scaffold were produced by slurry with ratio 10g:8ml of powder to water and addition of 2 wt. % of PVA and PEG and sintered at 1250°C for 2 hours. The optimum scaffold had 95.3% of porosity with unblock macropore, minimum crack and regular thickness of strut. In the second part, during biopolymer coating, single layer coating with higher PVA concentration had macropores blockage, while lower PVA concentration coating showed uncoated at interior of the scaffold. Bi-layer coating with PLA was to compensate the uncoated interior region in lower PVA concentration coated sample. In terms of mechanical property, compressive strength of the coated scaffold increased with the coated weight percentage of biopolymer. Polymer stretched at the crack opening showed crack bridging mechanism, which toughened the brittle β-TCP scaffold. Scaffold bi-layer coated with 3 wt. % of PVA and subsequently 5 wt. % PLA (V3_L5) had the highest compressive strength (83.7 kPa) with no macropore blocking by biopolymer. In terms of bioactivity, β-TCP without biopolymer coating took 2 weeks to form apatite but V3_L5 took 4 weeks after immersion in SBF. This showed that coating with hydrophobic PLA delayed the time of apatite formation. 2017-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf Wong, Wai Yee (2017) Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic T Technology
TA401-492 Materials of engineering and construction. Mechanics of materials
spellingShingle T Technology
TA401-492 Materials of engineering and construction. Mechanics of materials
Wong, Wai Yee
Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
description The interconnected porous β-TCP scaffold was produced via polyurethane (PU) foam replica method. PVA and/or PLA were coated on the scaffold to enhance the compressive strength. The first part of this study was to optimise the internal architecture of β-TCP scaffold with minimal defect before biopolymer coating. Optimum macro- and microporosity in β-TCP scaffold were produced by slurry with ratio 10g:8ml of powder to water and addition of 2 wt. % of PVA and PEG and sintered at 1250°C for 2 hours. The optimum scaffold had 95.3% of porosity with unblock macropore, minimum crack and regular thickness of strut. In the second part, during biopolymer coating, single layer coating with higher PVA concentration had macropores blockage, while lower PVA concentration coating showed uncoated at interior of the scaffold. Bi-layer coating with PLA was to compensate the uncoated interior region in lower PVA concentration coated sample. In terms of mechanical property, compressive strength of the coated scaffold increased with the coated weight percentage of biopolymer. Polymer stretched at the crack opening showed crack bridging mechanism, which toughened the brittle β-TCP scaffold. Scaffold bi-layer coated with 3 wt. % of PVA and subsequently 5 wt. % PLA (V3_L5) had the highest compressive strength (83.7 kPa) with no macropore blocking by biopolymer. In terms of bioactivity, β-TCP without biopolymer coating took 2 weeks to form apatite but V3_L5 took 4 weeks after immersion in SBF. This showed that coating with hydrophobic PLA delayed the time of apatite formation.
format Thesis
author Wong, Wai Yee
author_facet Wong, Wai Yee
author_sort Wong, Wai Yee
title Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_short Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_full Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_fullStr Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_full_unstemmed Fabrication Of 3d Porous Beta Tricalcium Phosphate Bone Scaffold Coated By Oly(Vinyl Alcohol) And Poly(Lactic Acid)_
title_sort fabrication of 3d porous beta tricalcium phosphate bone scaffold coated by oly(vinyl alcohol) and poly(lactic acid)_
publishDate 2017
url http://eprints.usm.my/46566/1/Fabrication%20Of%203d%20Porous%20Beta%20Tricalcium%20Phosphate%20Bone%20Scaffold%20Coated%20By%20Oly%28Vinyl%20Alcohol%29%20And%20Poly%28Lactic%20Acid%29_.pdf
http://eprints.usm.my/46566/
_version_ 1717094465184727040