Effects Of A Lactobacilli Probiotic On Survival And Mobility Of Female Drosophila Melanogaster With Alzheimer’s Disease
Alzheimer's disease (AD), as the most prevalent form of aging-associated neurodegenerative disease, progressed in an irreversible manner while approaching epidemic proportions with no cure or preventative therapy yet available. The probiotic strain Lactobacillus fermentum DR9 has been report...
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| Main Author: | |
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| Format: | Monograph |
| Language: | English |
| Published: |
Pusat Pengajian Teknologi Industri
2020
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| Online Access: | http://eprints.usm.my/46942/1/EFFECTS%20OF%20A%20LACTOBACILLI%20PROBIOTIC%20%28ABSTRACT%29.pdf http://eprints.usm.my/46942/ http://ethesis.usm.my:8080/jspui/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Alzheimer's disease (AD), as the most prevalent form of aging-associated
neurodegenerative disease, progressed in an irreversible manner while approaching
epidemic proportions with no cure or preventative therapy yet available. The probiotic
strain Lactobacillus fermentum DR9 has been reported for exhibiting anti-aging effects
on lifespan and muscle in senescence-induced rats, with AD-reversal potential by
alleviating neurodegeneration in the eye of AD-induced Drosophila. Using an
inducible Drosophila AD model by human Aβ42 expression with UAS/GAL4 system,
the study was carried out to evaluate the effects of probiotic administration on the
survival and mobility of female Drosophila melanogaster with AD. Evaluated by
survival assay, the administration of L. fermentum DR9 for 24 days improved survival
by increasing the survival percentage of female D. melanogaster AD model, as
compared to the untreated control. |
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