Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)

Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl a...

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Main Author:	Nowroji, Kavitha
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RA1190-1270 Toxicology. Poisons
Online Access:	http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf http://eprints.usm.my/47820/
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Institution:	Universiti Sains Malaysia
Language:	English

id	my.usm.eprints.47820
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spelling	my.usm.eprints.47820 http://eprints.usm.my/47820/ Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf) Nowroji, Kavitha RA1190-1270 Toxicology. Poisons Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl acetate fraction (PMEAF). Total phenolic content of PMEAF was expressed as 14.91 ± 0.97 mg GAE/g. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and CyQuant Cell Proliferation assay results indicated that PMEAF is a potential anticancer agent with the average IC50 values of 18.10 μg/mL. 2017-12 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf Nowroji, Kavitha (2017) Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf). PhD thesis, Universiti Sains Malaysia.
institution	Universiti Sains Malaysia
building	Hamzah Sendut Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Sains Malaysia
content_source	USM Institutional Repository
url_provider	http://eprints.usm.my/
language	English
topic	RA1190-1270 Toxicology. Poisons
spellingShingle	RA1190-1270 Toxicology. Poisons Nowroji, Kavitha Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
description	Phaleria macrocarpa is a well-known medicinal plant which exhibited cytotoxicity against various cancerous cells. The objective of this study was to determine the in vitro cytotoxicity effect by biochemical assay through the regulation of miRNAs on MDA-MB-231 treated with Phaleria macrocarpa ethyl acetate fraction (PMEAF). Total phenolic content of PMEAF was expressed as 14.91 ± 0.97 mg GAE/g. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and CyQuant Cell Proliferation assay results indicated that PMEAF is a potential anticancer agent with the average IC50 values of 18.10 μg/mL.
format	Thesis
author	Nowroji, Kavitha
author_facet	Nowroji, Kavitha
author_sort	Nowroji, Kavitha
title	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_short	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_full	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_fullStr	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_full_unstemmed	Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)
title_sort	study of cytotoxic mechanism and the role of microrna in mda-mb-231 cell lines treated with phaleria macrocarpa (boerl.) fruit ethyl acetate fraction (pmeaf)
publishDate	2017
url	http://eprints.usm.my/47820/1/STUDY%20OF%20CYTOTOXIC%20MECHANISM%20AND.pdf%20cut.pdf http://eprints.usm.my/47820/
_version_	1683231610450739200

Study Of Cytotoxic Mechanism And The Role Of Microrna In Mda-Mb-231 Cell Lines Treated With Phaleria Macrocarpa (Boerl.) Fruit Ethyl Acetate Fraction (Pmeaf)

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