Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives
Background: To screen and detect individuals at ultra high risk (UHR) for psychosis and evaluate the efficacy of a screening program. Methods: This a two-stage study involving relatives of patients with schizophrenia. The nonfirst degree relatives were additionally screened with the Screening Que...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2009
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| Subjects: | |
| Online Access: | http://eprints.usm.my/48690/1/DR.%20MOHD%20RAZALI%20SALLEH-OCR1.pdf http://eprints.usm.my/48690/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Background: To screen and detect individuals at ultra high risk (UHR) for psychosis and
evaluate the efficacy of a screening program.
Methods: This a two-stage study involving relatives of patients with schizophrenia. The nonfirst
degree relatives were additionally screened with the Screening Questionnaires ( SQ),
besides the GHQ-12 and GAF in the first stage. All the positive subjects will proceed to the
second stage assessment.
Results: Sixty four (14.2 %) of 450 selective relatives were positive in the first stage. In the
second stage, only 14 (3.1 %) were positive (UHR subject). The sensitivity of the SQ (67%)
was much better than the GHQ (29%), but the specificity was not much difference. The
d~t~ction rate of UHR individuals was higher in non-first degree relatives.
Implications: Screening of genetic risk relatives is feasible. The high detection rate among
non-first degree relatives is contributed by the addition of the SQ. The GHQ is not suitable
for screening in early psychosis. |
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