Simposium Kebudayaan Indonesia- Malaysia Ke -11 Bandung, Indonesia 10-12 November 2009
Malaria is one of the most devastating infectious diseases affecting much of the underdeveloped world with approximately 300-500 million people displaying clinical manifestations each year. Plasmodium falciparum is responsible for more then 90% of malaria cases in Africa and accounts for more tha...
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| Format: | Monograph |
| Language: | English |
| Published: |
Pusat Pengajian Sains Kesihatan
2009
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| Subjects: | |
| Online Access: | http://eprints.usm.my/54633/1/DR%20REPEAH%20SUPPIAN%20-%20e.pdf http://eprints.usm.my/54633/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Malaria is one of the most devastating infectious diseases affecting much of the
underdeveloped world with approximately 300-500 million people displaying clinical
manifestations each year. Plasmodium falciparum is responsible for more then 90% of
malaria cases in Africa and accounts for more than one million deaths annually. Due to
the emergence of insecticide-resistant mosquito · vectors and chloroquine-resistant
parasites in many parts of the world as well as the complexity of the parasite life cycle,
the development of a safe and effective malaria vaccine is urgently need to fight against
malaria. DNA vaccines have already been applied to deliver foreign antigens to the
immune system in a wide range of infectious diseases including malaria. In this study, a
DNA vaccine expressing the synthetic epitope of Plasmodium falciparum F2R(II)EBA
• has been constructed. Immunogenicity study in Balb/c mice showed that the candidate
vaccine is able to induce hwnoral immWle response against the epitope. This study
demonstrated the potential of using DNA vaccine to protect against malaria infections in
humans in the near future. |
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