Ultra-high performance liquid chromatography (uhplc) method development and validation for the determination of serum imatinib and its active metabolite concentration among chronic myeloid leukemia patients

• Main Author: Liong, Tan Ka
• Format: Thesis
• Language: English
• Published: 2013
• Subjects: R Medicine; RC254-282 Neoplasms. Tumors. Oncology (including Cancer); RC648-665 Diseases of the endocrine glands. Clinical endocrinology
• Online Access: http://eprints.usm.my/60900/1/TAN%20KA%20LIONG%20-%20e.pdf; http://eprints.usm.my/60900/
• Institution: Universiti Sains Malaysia

A simple and sensitive method for the simultaneous detection of imatinib mesylate and its active metabolite, N-desmethylimatinib, in human serum samples was developed. Separation was successfully achieved using an Agilent® ZORBAX Eclipse plus Cis reversed phase column (50 x 2.1 mm, i.d.; 1.8 pm) u...