Human G6PD variant structural studies: Elucidating the molecular basis of human G6PD deficiency

• Main Authors: Alakbaree, Maysaa, Amran, Sayazwani, Mohd Shamsir, Mohd Shamsir, H. Ahmed, Haron, Hamza, Muaawia, Alonazi, Mona, Warsy, Arjumand, Ab Latif, Nurriza
• Format: Article
• Language: English
• Published: Elsevier 2022
• Subjects: T Technology (General)
• Online Access: http://eprints.uthm.edu.my/7296/1/J14425_356b302151c30fc112ed7f8ac2a459d3%5B1%5D.pdf; http://eprints.uthm.edu.my/7296/; https://doi.org/10.1016/j.genrep.2022.101634
• Institution: Universiti Tun Hussein Onn Malaysia

Glucose-6-phosphate dehydrogenase deficiency is by far the most prevalent human enzymopathy and is gener�ated by a series of point mutations in the X-linked gene encoding G6PD. The severity of the deficiency relies on the various mutational sites in the gene, affecting the protein structure and fu...