The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor

A laboratory-scale up-flow anaerobic sludge blanket (UASB) reactor was deployed in this study to examine the relationship between pharmaceutical compounds and anaerobic process performance. The reactor successfully biotransformed up to 87–99% of psychostimulant caffeine, anti-diabetic drug gliclazid...

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Main Authors: Azizan, Nur Alyaa Zahida, Kamyab, Hesam, Yuzir, Ali, Abdullah, Norhayati, Kirpichnikova, Irina, Oryani, Bahareh, Rezania, Shahabaldin
Format: Article
Published: Elsevier Ltd 2022
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Online Access:http://eprints.utm.my/101217/
http://dx.doi.org/10.1016/j.biombioe.2022.106511
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Institution: Universiti Teknologi Malaysia
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spelling my.utm.1012172023-11-13T06:22:36Z http://eprints.utm.my/101217/ The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor Azizan, Nur Alyaa Zahida Kamyab, Hesam Yuzir, Ali Abdullah, Norhayati Kirpichnikova, Irina Oryani, Bahareh Rezania, Shahabaldin T Technology (General) A laboratory-scale up-flow anaerobic sludge blanket (UASB) reactor was deployed in this study to examine the relationship between pharmaceutical compounds and anaerobic process performance. The reactor successfully biotransformed up to 87–99% of psychostimulant caffeine, anti-diabetic drug gliclazide, and anti-hypertensive drug prazosin during 92 days of operation. At the same time, fluctuations were recorded for the methane gas production, and also the domination of acetic acid and propionic acid in the presence of pharmaceutical compounds was measured. The results from 16s rRNA sequencing revealed that these compounds stimulated the growth of hydrogenotrophic methanogens, mainly Methanobrevibacter and Methanobacterium, while shifting the compositions of hydrolytic and fermentative bacteria. These outcomes proved the capability of the pharmaceutical compounds to influence the process performance by changing the microbial compositions in the anaerobic reactor. Elsevier Ltd 2022 Article PeerReviewed Azizan, Nur Alyaa Zahida and Kamyab, Hesam and Yuzir, Ali and Abdullah, Norhayati and Kirpichnikova, Irina and Oryani, Bahareh and Rezania, Shahabaldin (2022) The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor. Biomass and Bioenergy, 163 (NA). pp. 1-8. ISSN 0961-9534 http://dx.doi.org/10.1016/j.biombioe.2022.106511 DOI : 10.1016/j.biombioe.2022.106511
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic T Technology (General)
spellingShingle T Technology (General)
Azizan, Nur Alyaa Zahida
Kamyab, Hesam
Yuzir, Ali
Abdullah, Norhayati
Kirpichnikova, Irina
Oryani, Bahareh
Rezania, Shahabaldin
The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
description A laboratory-scale up-flow anaerobic sludge blanket (UASB) reactor was deployed in this study to examine the relationship between pharmaceutical compounds and anaerobic process performance. The reactor successfully biotransformed up to 87–99% of psychostimulant caffeine, anti-diabetic drug gliclazide, and anti-hypertensive drug prazosin during 92 days of operation. At the same time, fluctuations were recorded for the methane gas production, and also the domination of acetic acid and propionic acid in the presence of pharmaceutical compounds was measured. The results from 16s rRNA sequencing revealed that these compounds stimulated the growth of hydrogenotrophic methanogens, mainly Methanobrevibacter and Methanobacterium, while shifting the compositions of hydrolytic and fermentative bacteria. These outcomes proved the capability of the pharmaceutical compounds to influence the process performance by changing the microbial compositions in the anaerobic reactor.
format Article
author Azizan, Nur Alyaa Zahida
Kamyab, Hesam
Yuzir, Ali
Abdullah, Norhayati
Kirpichnikova, Irina
Oryani, Bahareh
Rezania, Shahabaldin
author_facet Azizan, Nur Alyaa Zahida
Kamyab, Hesam
Yuzir, Ali
Abdullah, Norhayati
Kirpichnikova, Irina
Oryani, Bahareh
Rezania, Shahabaldin
author_sort Azizan, Nur Alyaa Zahida
title The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
title_short The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
title_full The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
title_fullStr The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
title_full_unstemmed The effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (UASB) reactor
title_sort effects of caffeine, gliclazide, and prazosin on the performance and microbial diversity in an up-flow anaerobic sludge blanket (uasb) reactor
publisher Elsevier Ltd
publishDate 2022
url http://eprints.utm.my/101217/
http://dx.doi.org/10.1016/j.biombioe.2022.106511
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