Electrospun nanofiber composites for drug delivery: a review on current progresses

• Main Authors: Jiffrin, Renatha, Abd. Razak, Saiful Izwan, Jamaludin, Mohamad Ikhwan, Amir Hamzah, Amir Syahir, Ahmad Mazian, Muadz, Tamar Jaya, Muhammad Azan, Nasrullah, Mohammed Z., Mohammed Majrashi, Mohammed Majrashi, Theyab, Abdulrahman, Aldarmahi, Ahmed A., Awan, Zuhier, Abdel Daim, Mohamed M., Azad, Abul Kalam
• Format: Article
• Language: English
• Published: MDPI 2022
• Subjects: Q Science (General); R Medicine (General)
• Online Access: http://eprints.utm.my/103856/1/SaifulIzwanAbd2022_ElectrospunNanofiberCompositesforDrug.pdf; http://eprints.utm.my/103856/; http://dx.doi.org/10.3390/polym14183725
• Institution: Universiti Teknologi Malaysia

A medication’s approximate release profile should be sustained in order to generate the desired therapeutic effect. The drug’s release site, duration, and rate must all be adjusted to the drug’s therapeutic aim. However, when designing drug delivery systems, this may be a considerable hurdle. Electrospinning is a promising method of creating a nanofibrous membrane since it enables drugs to be placed in the nanofiber composite and released over time. Nanofiber composites designed through electrospinning for drug release purposes are commonly constructed of simple structures. This nanofiber composite produces matrices with nanoscale fiber structure, large surface area to volume ratio, and a high porosity with small pore size. The nanofiber composite’s large surface area to volume ratio can aid with cell binding and multiplication, drug loading, and mass transfer processes. The nanofiber composite acts as a container for drugs that can be customized to a wide range of drug release kinetics. Drugs may be electrospun after being dissolved or dispersed in the polymer solution, or they can be physically or chemically bound to the nanofiber surface. The composition and internal structure of the nanofibers are crucial for medicine release patterns.