Imsea: A novel metabolite set enrichment analysis strategy to decipher drug interactions

• Main Authors: Wang, Yongpei, Liu, Xingxing, Dong, Liheng, Cheng, Kian-Kai, Lin, Caigui, Wang, Xiaomin, Dong, Jiyang, Deng, Lingli, Raftery, Daniel
• Format: Article
• Published: American Chemical Society 2023
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/105021/; http://dx.doi.org/10.1021/acs.analchem.2c04603
• Institution: Universiti Teknologi Malaysia

Drug combinations are commonly used to treat various diseases to achieve synergistic therapeutic effects or to alleviate drug resistance. Nevertheless, some drug combinations might lead to adverse effects, and thus, it is crucial to explore the mechanisms of drug interactions before clinical treatme...