Anticancer and cytotoxicity evaluation of silver-cinnamon nanoshells

• Main Authors: Salim, Ali Aqeel, Bakhtiar, Hazri, Dawood, Dawood Ali Salim, Ghoshal, Sib Krishna
• Format: Article
• Published: Elsevier B.V. 2023
• Subjects: QC Physics; QD Chemistry
• Online Access: http://eprints.utm.my/105585/; http://dx.doi.org/10.1016/j.matlet.2022.133671
• Institution: Universiti Teknologi Malaysia

New types of surface functionalized silver-cinnamon nanoshells (Ag-CNSs) were produced in deionized water using PLAL method and characterized. Anticancer effectiveness and cytotoxicity of these Ag-CNSs against liver hepatocellular carcinoma cancer (HepG2) and normal (WRL68) cell lines was evaluated. XRD and EDX analyses of Ag-CNSs showed their excellent crystallinity and elemental compositions. HRTEM micrographs displayed the existence of cinnamon protein-capped spherical Ag nanocrystallites of size 11.12 ± 1.32 nm. These ultra-sensitive Ag-CNSs with wide surface area revealed an improved fluorescence and surface plasmon resonance (SPR) absorption. The achieved Ag-CNSs exhibited strong anticancer activity (high cytotoxicity, log IC50 ≈ 59.1 %), indicating the feasibility of developing novel drugs for cancer cure. It was shown that via the surface functionalization, the anticancer efficacy of the proposed Ag-CNSs can be tailored.