Galactoside-based molecule enhanced antimicrobial activity through acyl moiety incorporation: synthesis and in silico exploration for therapeutic target

• Main Authors: Ahmmed, Faez, Al-Mijalli, Samiah Hamad, Abdallah, Emad M., Eissa, Ibrahim H., Ali, Ferdausi, Bhat, Ajmal R., Jamalis, Joazaizulfazli, Hadda, Taibi Ben, Kawsar, Sarkar M. A.
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/106208/1/JoazaizulfazliJamalis2023_GalactosideBasedMoleculeEnhancedAntimicrobial.pdf; http://eprints.utm.my/106208/; http://dx.doi.org/10.3390/ph16070998
• Institution: Universiti Teknologi Malaysia

In this study, a series of galactoside-based molecules, compounds of methyl β-d-galactopyranoside (MDGP, 1), were selectively acylated using 2-bromobenzoyl chloride to obtain 6-O-(2-bromobenzoyl) substitution products, which were then transformed into 2,3,4-tri-O-6-(2-bromobenzoyl) compounds (2–7) w...