An iterative GASVM-based method: gene selection and classification of microarray data
Microarray technology has provided biologists with the ability to measure the expression levels of thousands of genes in a single experiment. One of the urgent issues in the use of microarray data is the selection of a smaller subset of genes from the thousands of genes in the data that contributes...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book Section |
| Published: |
Springer
2009
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/14442/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Teknologi Malaysia |
| Summary: | Microarray technology has provided biologists with the ability to measure the expression levels of thousands of genes in a single experiment. One of the urgent issues in the use of microarray data is the selection of a smaller subset of genes from the thousands of genes in the data that contributes to a disease. This selection process is difficult due to many irrelevant genes, noisy genes, and the availability of the small number of samples compared to the huge number of genes (higher-dimensional data). In this study, we propose an iterative method based on hybrid genetic algorithms to select a near-optimal (smaller) subset of informative genes in classification of the microarray data. The experimental results show that our proposed method is capable in selecting the near-optimal subset to obtain better classification accuracies than other related previous works as well as four methods experimented in this work. Additionally, a list of informative genes in the best gene subsets is also presented for biological usage. |
|---|