A novel method for the production of crystalline micronised particles

• Main Authors: Syed Muhammad, Syed Anuar, Langrish, Tim Alan Granville, Tang, Patricia, Adi, Handoko, Chan, Hakkim, Kazarian, Sergei, Dehghani, Fariba
• Format: Article
• Published: Elsevier Ltd. 2010
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/22817/; https://doi.org/10.1016/j.ijpharm.2009.12.047
• Institution: Universiti Teknologi Malaysia

The aim of this study was to develop a method for converting an amorphous drug to a crystalline form to enhance its stability and inhalation performance. Spray-dried amorphous salbutamol sulphate powder was conditioned with supercritical carbon dioxide (scCO2) modified with menthol. The effect of me...