Water absorption and diffusion characteristics of Nano Hydroxyapatite (nHA) and Poly (hydroxybutyrate-co-hydroxyvale (PHBV)-Based Composite Tissue Engineering Scaffolds and Non-porous Thin Films

• Main Authors: Sultana, Naznin, Khan, Tareef Hayat
• Format: Article
• Published: Hindawi Publishing Corporation 2013
• Subjects: Q Science
• Online Access: http://eprints.utm.my/id/eprint/40777/; https://www.hindawi.com/journals/jnm/2013/479109/
• Institution: Universiti Teknologi Malaysia

Water uptake characteristics of poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV-) based composite tissue engineering (TE) scaffolds incorporating nanosized hydroxyapatite (nHA) have been investigated. The water absorption of these composite scaffolds obeyed the classical diffusion theory for the initial period of time. The diffusion coefficients of the composite scaffolds during the water absorption were much faster than those for the nonporous thin films, suggesting that the water uptake process depends on the presence of porosity and porous microstructure of the composite scaffolds. The incorporation of nHA increased the water uptake of both the composite scaffolds and thin films. It was also observed that the equilibrium uptake increased with the incorporation of nHA. This increase in the water uptake was largely due to the nHA particle aggregates in the microstructure of both composite scaffolds and thin films. The activation energy for diffusion was also determined using the Arrhenius equation for both porous scaffolds and thin films and the results suggested that the activation energy for scaffolds was lower than that for thin films.