Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 f...

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Main Authors:	Dev, Selvi, Prabhakaran, Praseetha, Filgueira, Luis, Iyer, K. Swaminathan, Raston, Colin L.
Format:	Article
Published:	The Royal Society of Chemistry 2012
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://eprints.utm.my/id/eprint/47211/ http://dx.doi.org/10.1039/c2nr11502f
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Institution:	Universiti Teknologi Malaysia

id	my.utm.47211
record_format	eprints
spelling	my.utm.472112019-03-31T08:34:51Z http://eprints.utm.my/id/eprint/47211/ Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. TA Engineering (General). Civil engineering (General) Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin. The Royal Society of Chemistry 2012 Article PeerReviewed Dev, Selvi and Prabhakaran, Praseetha and Filgueira, Luis and Iyer, K. Swaminathan and Raston, Colin L. (2012) Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent. Nanoscale, 4 (8). pp. 2575-2579. ISSN 2040-3364 http://dx.doi.org/10.1039/c2nr11502f DOI:10.1039/c2nr11502f
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
description	Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.
format	Article
author	Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L.
author_facet	Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L.
author_sort	Dev, Selvi
title	Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_short	Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_full	Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_fullStr	Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_full_unstemmed	Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_sort	microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
publisher	The Royal Society of Chemistry
publishDate	2012
url	http://eprints.utm.my/id/eprint/47211/ http://dx.doi.org/10.1039/c2nr11502f
_version_	1643652260329160704

Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

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