Overview on design considerations for development of disposable microbiorector prototypes

Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additi...

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Main Authors: Alam, M. N. H. Z., Zainal Alam, Muhd. Nazrul Hisham, Gernaey, Krist V.
Format: Article
Language:English
Published: Penerbit UTM Press 2012
Subjects:
Online Access:http://eprints.utm.my/id/eprint/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf
http://eprints.utm.my/id/eprint/47342/
https://jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/1268/1361
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Institution: Universiti Teknologi Malaysia
Language: English
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spelling my.utm.473422019-04-25T01:18:31Z http://eprints.utm.my/id/eprint/47342/ Overview on design considerations for development of disposable microbiorector prototypes Alam, M. N. H. Z. Zainal Alam, Muhd. Nazrul Hisham Gernaey, Krist V. TK Electrical engineering. Electronics Nuclear engineering Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additionally, by adapting polymer technology, microbioreactor can for example be made disposable. Thus, eliminates the need for cleaning of the reactor at the end of every experiment. Since typical working volumes of microbioreactors are less than 1 mL, this furthermore reduces substrate and utility consumption per experiment. Additionally, often a microbioreactor system is interfaced with optical measurements to acquire a real-time experimental data and thus, increases the amount of information gained per experiment. To design a microbioreactor system, one must consider the design of the entire system that drives the reactor and not just restrict the design only to the mechanical aspects of the reactor. In this paper, important design considerations as well as technical challenges for establishment of a microbioreactor to facilitate a typical aerobic fermentation processes are discussed. These include reactor operating feature and size, reactor mechanics (materials, fabrications, and mixing), reactor fluidics (connections, aeration, evaporation and feeding strategy), process control of physical parameters (temperature, pH, and dissolved oxygen level) and detection methods for measuring the cells concentration. Penerbit UTM Press 2012 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf Alam, M. N. H. Z. and Zainal Alam, Muhd. Nazrul Hisham and Gernaey, Krist V. (2012) Overview on design considerations for development of disposable microbiorector prototypes. Jurnal Teknologi (Sciences and Engineering), 59 . pp. 53-60. ISSN 0127-9696 https://jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/1268/1361
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TK Electrical engineering. Electronics Nuclear engineering
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
Alam, M. N. H. Z.
Zainal Alam, Muhd. Nazrul Hisham
Gernaey, Krist V.
Overview on design considerations for development of disposable microbiorector prototypes
description Microbioreactors are a miniaturized scale bioreactor system normally designed for bioprocess development. Such a microbioreactor design offer a new platform in carrying out cheap fermentation experiments under well controlled conditions – comparable to that of typical bench scale bioreactors. Additionally, by adapting polymer technology, microbioreactor can for example be made disposable. Thus, eliminates the need for cleaning of the reactor at the end of every experiment. Since typical working volumes of microbioreactors are less than 1 mL, this furthermore reduces substrate and utility consumption per experiment. Additionally, often a microbioreactor system is interfaced with optical measurements to acquire a real-time experimental data and thus, increases the amount of information gained per experiment. To design a microbioreactor system, one must consider the design of the entire system that drives the reactor and not just restrict the design only to the mechanical aspects of the reactor. In this paper, important design considerations as well as technical challenges for establishment of a microbioreactor to facilitate a typical aerobic fermentation processes are discussed. These include reactor operating feature and size, reactor mechanics (materials, fabrications, and mixing), reactor fluidics (connections, aeration, evaporation and feeding strategy), process control of physical parameters (temperature, pH, and dissolved oxygen level) and detection methods for measuring the cells concentration.
format Article
author Alam, M. N. H. Z.
Zainal Alam, Muhd. Nazrul Hisham
Gernaey, Krist V.
author_facet Alam, M. N. H. Z.
Zainal Alam, Muhd. Nazrul Hisham
Gernaey, Krist V.
author_sort Alam, M. N. H. Z.
title Overview on design considerations for development of disposable microbiorector prototypes
title_short Overview on design considerations for development of disposable microbiorector prototypes
title_full Overview on design considerations for development of disposable microbiorector prototypes
title_fullStr Overview on design considerations for development of disposable microbiorector prototypes
title_full_unstemmed Overview on design considerations for development of disposable microbiorector prototypes
title_sort overview on design considerations for development of disposable microbiorector prototypes
publisher Penerbit UTM Press
publishDate 2012
url http://eprints.utm.my/id/eprint/47342/1/MuhdNazrulZainalAlam2012_OverviewonDesignConsiderationsforDevelopment.pdf
http://eprints.utm.my/id/eprint/47342/
https://jurnalteknologi.utm.my/index.php/jurnalteknologi/article/view/1268/1361
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