A low-voltage and label-free impedance-based miniaturized CMOS biosensor for DNA detection

This study designs a low-voltage, label-free and fully integrated impedance-based biosensor using standard complementary metal oxide semiconductor (CMOS) technology to compute both capacitance and resistance of the electrode-electrolyte interface. The proposed biosensor circuit is composed of a comm...

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Bibliographic Details
Main Authors: Fan, Vinny Lam Siu, Wong, How Hwan, Yusof, Yusmeeraz
Format: Article
Language:English
Published: Penerbit UTM 2014
Subjects:
Online Access:http://eprints.utm.my/id/eprint/51511/1/VinnyLamSiu2014_Alow-voltageandlabel-free.pdf
http://eprints.utm.my/id/eprint/51511/
http://dx.doi.org/10.11113/jt.v67.2056
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Institution: Universiti Teknologi Malaysia
Language: English
Description
Summary:This study designs a low-voltage, label-free and fully integrated impedance-based biosensor using standard complementary metal oxide semiconductor (CMOS) technology to compute both capacitance and resistance of the electrode-electrolyte interface. The proposed biosensor circuit is composed of a commongate transimpedance amplifier (CG-TIA) with two quadrature phase Gilbert cell double-balanced mixers and finally integrated with microelectrode using 0.18 μm Silterra CMOS technology process. The output value of the readout circuit was used to estimate the magnitude and phase of the measured admittance. The developed CG-TIA can achieve a gain of 88.6 dB up to a frequency of 50 MHz. The overall dynamic range was approximately 116 dB