Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications
Tissue engineering fibrous scaffolds serve as three-dimensional (3D) environmental framework by mimicking the extracellular matrix (ECM) for cells to grow. Biodegradable polycaprolactone (PCL) microfibers were fabricated to mimic the ECM as a scaffold with 7.5% (w/v) and 12.5% (w/v) concentrations....
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my.utm.528482018-07-04T11:52:23Z http://eprints.utm.my/id/eprint/52848/ Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications Hassan, Mohd. Izzat Sun, Tao Sultana, Naznin QH Natural history Tissue engineering fibrous scaffolds serve as three-dimensional (3D) environmental framework by mimicking the extracellular matrix (ECM) for cells to grow. Biodegradable polycaprolactone (PCL) microfibers were fabricated to mimic the ECM as a scaffold with 7.5% (w/v) and 12.5% (w/v) concentrations. Lower PCL concentration of 7.5% (w/v) resulted in microfibers with bead defects. The average diameter of fibers increased at higher voltage and the distance of tip to collector. Further investigation was performed by the incorporation of nanosized hydroxyapatite (nHA) into microfibers. The incorporation of 10% (w/w) nHA with 7.5% (w/v) PCL solution produced submicron sized beadless fibers. The microfibrous scaffolds were evaluated using various techniques. Biodegradable PCL and nHA/PCL could be promising for tissue engineering scaffold application. Hindawi Publishing Corporation 2014 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/52848/1/MohdIzzatHassan2014_FabricationofNanohydroxyapatite.pdf Hassan, Mohd. Izzat and Sun, Tao and Sultana, Naznin (2014) Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications. Journal of Nanomaterials . ISSN 1687-4110 http://dx.doi.org/10.1155/2014/209049 DOI: 10.1155/2014/209049 |
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QH Natural history Hassan, Mohd. Izzat Sun, Tao Sultana, Naznin Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
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Tissue engineering fibrous scaffolds serve as three-dimensional (3D) environmental framework by mimicking the extracellular matrix (ECM) for cells to grow. Biodegradable polycaprolactone (PCL) microfibers were fabricated to mimic the ECM as a scaffold with 7.5% (w/v) and 12.5% (w/v) concentrations. Lower PCL concentration of 7.5% (w/v) resulted in microfibers with bead defects. The average diameter of fibers increased at higher voltage and the distance of tip to collector. Further investigation was performed by the incorporation of nanosized hydroxyapatite (nHA) into microfibers. The incorporation of 10% (w/w) nHA with 7.5% (w/v) PCL solution produced submicron sized beadless fibers. The microfibrous scaffolds were evaluated using various techniques. Biodegradable PCL and nHA/PCL could be promising for tissue engineering scaffold application. |
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Article |
author |
Hassan, Mohd. Izzat Sun, Tao Sultana, Naznin |
author_facet |
Hassan, Mohd. Izzat Sun, Tao Sultana, Naznin |
author_sort |
Hassan, Mohd. Izzat |
title |
Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
title_short |
Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
title_full |
Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
title_fullStr |
Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
title_full_unstemmed |
Fabrication of Nanohydroxyapatite/Poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
title_sort |
fabrication of nanohydroxyapatite/poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications |
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Hindawi Publishing Corporation |
publishDate |
2014 |
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http://eprints.utm.my/id/eprint/52848/1/MohdIzzatHassan2014_FabricationofNanohydroxyapatite.pdf http://eprints.utm.my/id/eprint/52848/ http://dx.doi.org/10.1155/2014/209049 |
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