Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol

• Main Authors: Cheng, Kian Kai, Lee, Baek Seok, Masuda, Takeshi, Ito, Takuro, Ikeda, Kazutaka, Hirayama, Akiyoshi, Deng, Lingli, Dong, Jiyang, Shimizu, Kazuyuki, Soga, Tomoyoshi, Tomita, Masaru, Palsson, Bernhard O, Robert, Martin
• Format: Article
• Language: English
• Published: Nature Publishing Group 2014
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/52981/1/ChengKianKai2014_GlobalMetabolicNetworkReorganizationbyAdaptive.pdf; http://eprints.utm.my/id/eprint/52981/; http://dx.doi.org/10.1038/ncomms4233
• Institution: Universiti Teknologi Malaysia

Comparative whole-genome sequencing enables the identification of specific mutations during adaptation of bacteria to new environments and allelic replacement can establish their causality. However, the mechanisms of action are hard to decipher and little has been achieved for epistatic mutations, e...