Metabolomic analysis of Akt1-mediated muscle hypertrophy in models of diet-induced obesity and age-related fat accumulation

• Main Authors: Cheng, Kian Kai, Akasaki, Yuichi, Lecommandeur, Emmanuell, Lindsay, Ross T., Murfitt, Steven A., Walsh, Kenneth, Griffin, Julian L.
• Format: Article
• Language: English
• Published: American Chemical Society 2014
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/54085/1/ChengKianKai2014_MetabolomicanalysisofAkt1.pdf; http://eprints.utm.my/id/eprint/54085/; http://dx.doi.org/10.1021/pr500756u
• Institution: Universiti Teknologi Malaysia

Akt1 is a serine/threonine kinase that promotes cell growth and survival. Previously, Akt1 activation in a double transgenic (DTG) mouse model fed a high-fat/high-sucrose (HF/HS) diet was found to promote type IIb muscle growth and to lead to a significant reduction in obesity. Here, we have used me...