Flavonoids from artocarpus anisophyllus and their bioactivities

Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artoca...

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Main Authors: Abdul Lathiff, Siti Mariam, Jemaon, Noraini, Abdullah, Siti Awanis, Jamil, Shajarahtunnur
Format: Article
Published: Natural Product Incorporation 2015
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Online Access:http://eprints.utm.my/id/eprint/55311/
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Institution: Universiti Teknologi Malaysia
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spelling my.utm.553112017-02-15T07:09:38Z http://eprints.utm.my/id/eprint/55311/ Flavonoids from artocarpus anisophyllus and their bioactivities Abdul Lathiff, Siti Mariam Jemaon, Noraini Abdullah, Siti Awanis Jamil, Shajarahtunnur QD Chemistry Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 µg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 µg/mL. Natural Product Incorporation 2015-03 Article PeerReviewed Abdul Lathiff, Siti Mariam and Jemaon, Noraini and Abdullah, Siti Awanis and Jamil, Shajarahtunnur (2015) Flavonoids from artocarpus anisophyllus and their bioactivities. Natural Product Communications, 10 (3). pp. 393-396. ISSN 1934-578X
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Abdul Lathiff, Siti Mariam
Jemaon, Noraini
Abdullah, Siti Awanis
Jamil, Shajarahtunnur
Flavonoids from artocarpus anisophyllus and their bioactivities
description Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 µg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 µg/mL.
format Article
author Abdul Lathiff, Siti Mariam
Jemaon, Noraini
Abdullah, Siti Awanis
Jamil, Shajarahtunnur
author_facet Abdul Lathiff, Siti Mariam
Jemaon, Noraini
Abdullah, Siti Awanis
Jamil, Shajarahtunnur
author_sort Abdul Lathiff, Siti Mariam
title Flavonoids from artocarpus anisophyllus and their bioactivities
title_short Flavonoids from artocarpus anisophyllus and their bioactivities
title_full Flavonoids from artocarpus anisophyllus and their bioactivities
title_fullStr Flavonoids from artocarpus anisophyllus and their bioactivities
title_full_unstemmed Flavonoids from artocarpus anisophyllus and their bioactivities
title_sort flavonoids from artocarpus anisophyllus and their bioactivities
publisher Natural Product Incorporation
publishDate 2015
url http://eprints.utm.my/id/eprint/55311/
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