Flavonoids from artocarpus anisophyllus and their bioactivities
Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artoca...
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my.utm.553112017-02-15T07:09:38Z http://eprints.utm.my/id/eprint/55311/ Flavonoids from artocarpus anisophyllus and their bioactivities Abdul Lathiff, Siti Mariam Jemaon, Noraini Abdullah, Siti Awanis Jamil, Shajarahtunnur QD Chemistry Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 µg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 µg/mL. Natural Product Incorporation 2015-03 Article PeerReviewed Abdul Lathiff, Siti Mariam and Jemaon, Noraini and Abdullah, Siti Awanis and Jamil, Shajarahtunnur (2015) Flavonoids from artocarpus anisophyllus and their bioactivities. Natural Product Communications, 10 (3). pp. 393-396. ISSN 1934-578X |
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QD Chemistry Abdul Lathiff, Siti Mariam Jemaon, Noraini Abdullah, Siti Awanis Jamil, Shajarahtunnur Flavonoids from artocarpus anisophyllus and their bioactivities |
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Two new prenylated flavonoids, 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-y,y-dimethylallylflavone 1 and 3'-hydroxycycloartocarpin 2 along with six known flavonoids, 5,7-dihydroxy-4'-methoxy-8-prenylflavanone 3, isobavachalcone 4, pyranocycloartobiloxanthone A 5, artocarpin 6, chaplashin 7 and cycloartocarpin 8 were isolated for the first time from the leaves and the heartwoods of Artocarpus anisophyllus Miq. The structures of isolated flavonoids were elucidated spectroscopically using 1D and 2D NMR, FTIR, MS, UV and also by comparison with literature data. These flavonoids were screened for their antioxidant and tyrosinase inhibitory activities. The dichloromethane and ethyl acetate crude extracts together with 3'-hydroxycycloartocarpin 2, pyranocycloartobiloxanthone A 5 and artocarpin 6 showed DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity with SC50 values of 80.2, 40.0, 152.9, 20.2 and 140.0 µg/mL in 30 min, respectively. Pyranocycloartobiloxanthone A 5 exhibited significant tyrosinase inhibitory activity against tyrosinase from mushroom with IC50 values of 60.5 µg/mL. |
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Article |
author |
Abdul Lathiff, Siti Mariam Jemaon, Noraini Abdullah, Siti Awanis Jamil, Shajarahtunnur |
author_facet |
Abdul Lathiff, Siti Mariam Jemaon, Noraini Abdullah, Siti Awanis Jamil, Shajarahtunnur |
author_sort |
Abdul Lathiff, Siti Mariam |
title |
Flavonoids from artocarpus anisophyllus and their bioactivities |
title_short |
Flavonoids from artocarpus anisophyllus and their bioactivities |
title_full |
Flavonoids from artocarpus anisophyllus and their bioactivities |
title_fullStr |
Flavonoids from artocarpus anisophyllus and their bioactivities |
title_full_unstemmed |
Flavonoids from artocarpus anisophyllus and their bioactivities |
title_sort |
flavonoids from artocarpus anisophyllus and their bioactivities |
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Natural Product Incorporation |
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2015 |
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http://eprints.utm.my/id/eprint/55311/ |
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