Chiral separation of four stereoisomers of ketoconazole drugs using capillary electrophoresis

• Main Authors: Wan Ibrahim, Wan Aini, Arsad, Siti Rosilah, Maarof, Hasmerya, Sanagi, Mohd. Marsin, Aboul Enein, Hassan Y.
• Format: Article
• Published: John Wiley and Sons Inc. 2015
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/58046/; http://dx.doi.org/10.1002/chir.22416
• Institution: Universiti Teknologi Malaysia

This work aimed to develop a chiral separation method of ketoconazole enantiomers using electrokinetic chromatography. The separation was achieved using heptakis (2, 3, 6-tri-O-methyl)-β-cyclodextrin (TMβCD), a commonly used chiral selector (CS), as it is relatively inexpensive and has a low UV abso...