Design of fully integrated impedimetric CMOS biosensor for DNA detection
This paper described a label-free and fully integrated impedimetric biosensor using standard Complementary Metal Oxide Semiconductor (CMOS) technology to measure both capacitance and resistance of the electrode-electrolyte interface. Conventional impedance biosensors usually use bulky and expensive...
Saved in:
Main Authors: | , |
---|---|
Format: | Article |
Published: |
Universiti Malaysia Perlis
2015
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/58240/ http://dx.doi.org/10.4028/www.scientific.net/AMR.925.524 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universiti Teknologi Malaysia |
id |
my.utm.58240 |
---|---|
record_format |
eprints |
spelling |
my.utm.582402021-08-22T06:33:26Z http://eprints.utm.my/id/eprint/58240/ Design of fully integrated impedimetric CMOS biosensor for DNA detection Lam, Vinny Siu Fan Yusof, Yusmeeraz TK Electrical engineering. Electronics Nuclear engineering This paper described a label-free and fully integrated impedimetric biosensor using standard Complementary Metal Oxide Semiconductor (CMOS) technology to measure both capacitance and resistance of the electrode-electrolyte interface. Conventional impedance biosensors usually use bulky and expensive instruments to monitor the impedance change. This paper demonstrates a low power, high gain and low cost impedance readout circuit design for detecting the biomolecular interactions of deoxyribonucleic acid (DNA) strands at the electrode surface. The proposed biosensor circuit is composed of a transimpedance amplifier (TIA) with two quadrature phase mixers and finally integrated with 5µm x 5µm microelectrode based on 0.18µm Silterra CMOS technology process with 1.8V supply. The output value of the readout circuit is used to estimate the amplitude and phase of the measured admittance. The developed TIA can achieve a gain of 88.6dB up to a frequency of 50MHz. It also has very good linearity up to 2.7mA and the overall dynamic range is approximately 90dB. Universiti Malaysia Perlis 2015 Article PeerReviewed Lam, Vinny Siu Fan and Yusof, Yusmeeraz (2015) Design of fully integrated impedimetric CMOS biosensor for DNA detection. International Journal Of Nanoelectronics And Materials, 8 (1). pp. 55-60. ISSN 1985-4668 http://dx.doi.org/10.4028/www.scientific.net/AMR.925.524 DOI: 10.4028/www.scientific.net/AMR.925.524 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
topic |
TK Electrical engineering. Electronics Nuclear engineering |
spellingShingle |
TK Electrical engineering. Electronics Nuclear engineering Lam, Vinny Siu Fan Yusof, Yusmeeraz Design of fully integrated impedimetric CMOS biosensor for DNA detection |
description |
This paper described a label-free and fully integrated impedimetric biosensor using standard Complementary Metal Oxide Semiconductor (CMOS) technology to measure both capacitance and resistance of the electrode-electrolyte interface. Conventional impedance biosensors usually use bulky and expensive instruments to monitor the impedance change. This paper demonstrates a low power, high gain and low cost impedance readout circuit design for detecting the biomolecular interactions of deoxyribonucleic acid (DNA) strands at the electrode surface. The proposed biosensor circuit is composed of a transimpedance amplifier (TIA) with two quadrature phase mixers and finally integrated with 5µm x 5µm microelectrode based on 0.18µm Silterra CMOS technology process with 1.8V supply. The output value of the readout circuit is used to estimate the amplitude and phase of the measured admittance. The developed TIA can achieve a gain of 88.6dB up to a frequency of 50MHz. It also has very good linearity up to 2.7mA and the overall dynamic range is approximately 90dB. |
format |
Article |
author |
Lam, Vinny Siu Fan Yusof, Yusmeeraz |
author_facet |
Lam, Vinny Siu Fan Yusof, Yusmeeraz |
author_sort |
Lam, Vinny Siu Fan |
title |
Design of fully integrated impedimetric CMOS biosensor for DNA detection |
title_short |
Design of fully integrated impedimetric CMOS biosensor for DNA detection |
title_full |
Design of fully integrated impedimetric CMOS biosensor for DNA detection |
title_fullStr |
Design of fully integrated impedimetric CMOS biosensor for DNA detection |
title_full_unstemmed |
Design of fully integrated impedimetric CMOS biosensor for DNA detection |
title_sort |
design of fully integrated impedimetric cmos biosensor for dna detection |
publisher |
Universiti Malaysia Perlis |
publishDate |
2015 |
url |
http://eprints.utm.my/id/eprint/58240/ http://dx.doi.org/10.4028/www.scientific.net/AMR.925.524 |
_version_ |
1709667334868697088 |