Synthesis of biodegradable polyester by polycondensation with tunable properties
A biodegradable cross-linked polyester, poly(1, 8-octanediol-glycerol-dodecanedioate) (POGDA) was prepared from 1, 8-octanediol (Oct), glycerol (Gly) and dodecanedioic acid (DA) without any catalyst. One of the factors, molar ratio of monomers greatly affects the material properties of POGDA and the...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/59082/ https://www.scientific.net/AMR.1119.418 |
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| Institution: | Universiti Teknologi Malaysia |
| Summary: | A biodegradable cross-linked polyester, poly(1, 8-octanediol-glycerol-dodecanedioate) (POGDA) was prepared from 1, 8-octanediol (Oct), glycerol (Gly) and dodecanedioic acid (DA) without any catalyst. One of the factors, molar ratio of monomers greatly affects the material properties of POGDA and the effect was evaluated. Result showed that the glycerol acts as crosslink agent. When the molar ratio of glycerol increased, the gel content of POGDA became higher. POGDA has a range of glass transition temperature (T<sub>g</sub>) with different monomers' molar ratio. Exist of melting point (T<sub>m</sub>) indicated the crystallline region in the polymer. POGDA with low molar ratio of glycerol has high T<sub>m</sub> due to the bigger region of crystal. In vitro degradation was performed to investigate the biodegradation behaviour of POGDA. The polymer with tunable material properties by tailoring monomers' molar ratio is expected to have broad application in medical fields such as drug delivery systems and tissue engineering. |
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