Formulation and characterization of [6]-gingerol loaded nanostructured lipid carrier (NLC)

• Main Authors: Rosli, Nur Ayshah, Mohamed Noor, Norhayati, Abdul Aziz, Ramlan, Abd. Aziz, Azila, Hasham, Rosnani
• Format: Conference or Workshop Item
• Language: English
• Published: 2014
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/61232/1/RosnaniHasham%40Hisam2014_FormulationandCharacterizationof6Gingerol.pdf; http://eprints.utm.my/id/eprint/61232/
• Institution: Universiti Teknologi Malaysia

Nanostructured lipid carrier (NLC) is the blend of solid lipid, liquid lipid and suitable surfactant for the purpose of encapsulated poorly water soluble drugs. [6]-gingerol is the main bioactive compound in Zingiber officinale, widely known as ginger in Malaysia. Zingiber officinale extract has been discovered to have anti-oxidant, anti-inflammatory, and anti-microbial effects to human body. The aim of this study is to develop NLC formulation for [6]-gingerol and to estimate the potential of NLC as a delivery system for these water insoluble drugs. In this work, the preparation of ginger oil loaded onto nanostructured lipid carrier (GO-NLC) was done by using ultrasonication method. The GO-NLCs were assessed by evaluating the morphology and its entrapment efficiency. The morphological study was performed by using Zetasizer Nano S and the entrapment efficiency analysis of NLC was performed using HPLC by detecting [6]-gingerol as active biomarker. The average particle size for GO-NLCs ranged from size 100 to 250 nm and the average encapsulation efficiency was 92.7± 3.03%.Based on analysis, it is proved that nanostructured lipid carriers has high potential to be nanocarriers for [6]-gingerol.