Synthesis, characterization, POM analysis and antifungal activity of novel heterocyclic chalcone derivatives containing acylated pyrazole

• Main Authors: Abdulghani Al-Maqtari, Joazaizulfazli, Jamalis, Hasnah, Taibi, Ben Hadda, Sankaranarayanan, Murugesan, Noor, Aisyah Ahmad, Mohd. Sirat, Hasnah, Althagafi, Ismail I., Mabkhot, Yahia Nasser
• Format: Article
• Published: Springer Netherlands 2017
• Subjects: Q Science
• Online Access: http://eprints.utm.my/id/eprint/66201/; http://dx.doi.org/10.1007/s11164-016-2737-y
• Institution: Universiti Teknologi Malaysia

A series of heterocyclic chalcone derivatives (4a–h) were synthesized and characterized by IR, 1H and 13C NMR as well as MS. All the synthesized compounds were evaluated for their antifungal activity on Candida albicans and Aspergillus niger. The assay revealed that compounds 3d and 4f showed signif...