Identification of informative genes and pathways using an improved penalized support vector machine with a weighting scheme

• Main Authors: Weng, Howe Chan, Tan Ah Chik @ Mohamad, Mohd Saberi, Deris, Safaai, Zaki, Nazar, Kasim, Shahreen, Omatu, Sigeru, Juan, Manuel Corchado, Hany, Al Ashwal
• Format: Article
• Published: ELSEVIER 2016
• Subjects: QA75 Electronic computers. Computer science
• Online Access: http://eprints.utm.my/id/eprint/68183/; http://dx.doi.org/10.1016/j.compbiomed.2016.08.004
• Institution: Universiti Teknologi Malaysia

Incorporation of pathway knowledge into microarray analysis has brought better biological interpreta- tion of the analysis outcome. However, most pathway data are manually curated without speci fi c bio- logical context. Non-informative genes could be included when the pathway data is used for analy...