Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis...
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2016
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my.utm.725042017-11-27T00:30:26Z http://eprints.utm.my/id/eprint/72504/ Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. QD Chemistry Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. Elsevier Ltd 2016 Article PeerReviewed Salleh, W. M. N. H. W. and Ahmad, F. and Khong, H. Y. and Zulkifli, R. M. and Chen, J. J. and Nahar, L. and Wansi, J. D. and Sarker, S. D. (2016) Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra. Phytochemistry Letters, 16 . pp. 192-196. ISSN 1874-3900 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799 |
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QD Chemistry Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| description |
Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays. |
| format |
Article |
| author |
Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. |
| author_facet |
Salleh, W. M. N. H. W. Ahmad, F. Khong, H. Y. Zulkifli, R. M. Chen, J. J. Nahar, L. Wansi, J. D. Sarker, S. D. |
| author_sort |
Salleh, W. M. N. H. W. |
| title |
Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| title_short |
Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| title_full |
Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| title_fullStr |
Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| title_full_unstemmed |
Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra |
| title_sort |
beilschglabrines a and b: two new bioactive phenanthrene alkaloids from the stem bark of beilschmiedia glabra |
| publisher |
Elsevier Ltd |
| publishDate |
2016 |
| url |
http://eprints.utm.my/id/eprint/72504/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799 |
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