Synthesis, characterization, and cytotoxic activities of heterocyclic chalcones containing furan, and crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one
A series of heterocyclic chalcone (3a–e, 5, 7) were synthesized and characterized by Infrared, 1H and 13C nuclear magnetic resonance, and mass spectra. Crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one was determined using single crystal X-ray diffraction. All the synthesiz...
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| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Taylor and Francis Inc.
2016
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/72526/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978909746&doi=10.1080%2f15421406.2016.1149025&partnerID=40&md5=d8ede1a18d952371e32cba364334169f |
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| Institution: | Universiti Teknologi Malaysia |
| Summary: | A series of heterocyclic chalcone (3a–e, 5, 7) were synthesized and characterized by Infrared, 1H and 13C nuclear magnetic resonance, and mass spectra. Crystal structure of 1-(4-iodophenyl)-3-(5-methylfuran-2-yl)prop-2-en-1-one was determined using single crystal X-ray diffraction. All the synthesized compounds were evaluated for their cytotoxic activities on MDA MB 231 and CHO cell by using MTT assay. Compound 3c showed good cytotoxic effect on MDA MB 231 with IC50 values of 9.8 µg/mL. |
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