Madangones A and B: two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities

• Main Authors: Salleh, W.M.N.H.W., Ahmad, F., Yen, K.H., Zulkifli, R.M., Sarker, S.D.
• Format: Article
• Published: Elsevier Ltd 2016
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/73826/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954270929&doi=10.1016%2fj.phytol.2016.01.004&partnerID=40&md5=399a7a02c3ad70d2c3179f6737994078
• Institution: Universiti Teknologi Malaysia

Two new neolignans, madangones A (1) and B (2), together with (+)-kunstlerone (3), vanillin, vanillic acid, betulin, β-sitosterol and β-sitostenone, were isolated from the stem bark of Beilschmiedia madang (Lauraceae). The structures of the compounds were determined by spectroscopic means. The compounds were tested for antioxidant, acetylcholinesterase inhibitory and anti-inflammatory activities. Compound (3) displayed the strongest DPPH radical-scavenging activity with an IC50 value of 68.7 μM. Compound (2) exhibited the highest level of activity on the COX-2 model and acetylcholinesterase inhibition assay, with IC50 values of 27.4 and 70.3 μM, respectively.