Antioxidant and anti-inflammatory activities of essential oils of Actinodaphne macrophylla and A. pruinosa (Lauraceae)

• Main Authors: Wan Salleh, Wan Mohd. Nuzul Hakimi, Ahmad, Farediah
• Format: Article
• Published: Natural Product Incorporation 2016
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/74161/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84989183252&partnerID=40&md5=1e721ead1bfe8e6190ee83fe57bfa4a8
• Institution: Universiti Teknologi Malaysia

The essential oils of Actinodaphne macrophylla and A. pruinosa were analyzed by GC and GC-MS and evaluated for their antioxidant and anti-inflammatory activities.The essential oil of the leaves of A. macrophylla was characterized by the presence of 31 components (78.2%), with germacrene B (16.8%) and globulol (16.0%) as the major components. A total of 28 components (71.6%) were characterized in the leaf oil of A. pruinosa with the most abundant components being globulol (17.8%) and spathulenol (12.0%). The antioxidant activity was determined by DPPH radical scavenging and total phenolic content, while anti-inflammatory activity by lipoxygenase assay. The essential oil of A. pruinosa demonstrated significant activity on DPPH (IC50 85.6 μg/mL), phenolic content (190.2 mg GA/g) and in the lipoxygenase (IC5085.2 μM) assays.