In vitro permeation and skin retention of a-mangostin proniosome

• Main Authors: Chin, G. S., Todo, H., Kadhum, W. R., Hamid, M. A., Sugibayashi, K.
• Format: Article
• Published: Pharmaceutical Society of Japan 2016
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/74446/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85000842886&doi=10.1248%2fcpb.c16-00425&partnerID=40&md5=f0e35ee9a9bbbf02fd85d550cf437d25
• Institution: Universiti Teknologi Malaysia

The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application.