A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate

Being the prevailing approach for producing esters such as butyl butyrate, the use of chemical route has been linked to numerous disadvantages. Hence, a green alternative method for higher yield production of butyl butyrate by esterification reaction utilizing Novozyme 435 as biocatalysts in a solve...

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Main Authors: Rahman, I. N. A., Manan, F. M. A., Marzuki, N. H. C., Mahat, N. A., Attan, N., Keyon, A. S. A., Jamalis, J., Aboul-Enein, H. Y., Wahab, R. A.
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Published: Penerbit UTM Press 2017
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Online Access:http://eprints.utm.my/id/eprint/76681/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032287415&doi=10.11113%2fjt.v79.10194&partnerID=40&md5=4eb07e55f47a2ca408b6c96176e52734
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spelling my.utm.766812018-04-30T13:50:12Z http://eprints.utm.my/id/eprint/76681/ A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate Rahman, I. N. A. Manan, F. M. A. Marzuki, N. H. C. Mahat, N. A. Attan, N. Keyon, A. S. A. Jamalis, J. Aboul-Enein, H. Y. Wahab, R. A. QD Chemistry Being the prevailing approach for producing esters such as butyl butyrate, the use of chemical route has been linked to numerous disadvantages. Hence, a green alternative method for higher yield production of butyl butyrate by esterification reaction utilizing Novozyme 435 as biocatalysts in a solvent-less system may prove useful. Such approach can be further improved by optimizing the relevant reaction parameters using the Response Surface Methodology by the Box-Benkhen Design attempted in this present study. The reaction parameters evaluated were: substrate molar ratio, time and temperature, and the response of each parameter was measured as percentage conversion yield. Using the Design Expert 7.1.6 optimization functions, the two sets of optimum conditions selected viz. [i] molar ratio butyric acid:butanol 1:3.93, 9.93 h at 56.09°C and [ii] molar ratio butyric acid:butanol 1:3.35, 9.79 h at 53.90°C had afforded the highest yield of butyl butyrate i.e. 99.62% and 99.55%, respectively. The ester product obtained from the reaction were confirmed as butyl butyrate by FTIR and GC. Therefore, the results substantiated the applicability of the RSM prediction technique as well as efficacy of Novozyme 435 as biocatalysts in the high yield solvent-less synthesis of butyl butyrate, adhering to the philosophy of Green Chemistry. Penerbit UTM Press 2017 Article PeerReviewed Rahman, I. N. A. and Manan, F. M. A. and Marzuki, N. H. C. and Mahat, N. A. and Attan, N. and Keyon, A. S. A. and Jamalis, J. and Aboul-Enein, H. Y. and Wahab, R. A. (2017) A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate. Jurnal Teknologi, 79 (7). pp. 141-151. ISSN 0127-9696 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032287415&doi=10.11113%2fjt.v79.10194&partnerID=40&md5=4eb07e55f47a2ca408b6c96176e52734 DOI:10.11113/jt.v79.10194
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic QD Chemistry
spellingShingle QD Chemistry
Rahman, I. N. A.
Manan, F. M. A.
Marzuki, N. H. C.
Mahat, N. A.
Attan, N.
Keyon, A. S. A.
Jamalis, J.
Aboul-Enein, H. Y.
Wahab, R. A.
A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
description Being the prevailing approach for producing esters such as butyl butyrate, the use of chemical route has been linked to numerous disadvantages. Hence, a green alternative method for higher yield production of butyl butyrate by esterification reaction utilizing Novozyme 435 as biocatalysts in a solvent-less system may prove useful. Such approach can be further improved by optimizing the relevant reaction parameters using the Response Surface Methodology by the Box-Benkhen Design attempted in this present study. The reaction parameters evaluated were: substrate molar ratio, time and temperature, and the response of each parameter was measured as percentage conversion yield. Using the Design Expert 7.1.6 optimization functions, the two sets of optimum conditions selected viz. [i] molar ratio butyric acid:butanol 1:3.93, 9.93 h at 56.09°C and [ii] molar ratio butyric acid:butanol 1:3.35, 9.79 h at 53.90°C had afforded the highest yield of butyl butyrate i.e. 99.62% and 99.55%, respectively. The ester product obtained from the reaction were confirmed as butyl butyrate by FTIR and GC. Therefore, the results substantiated the applicability of the RSM prediction technique as well as efficacy of Novozyme 435 as biocatalysts in the high yield solvent-less synthesis of butyl butyrate, adhering to the philosophy of Green Chemistry.
format Article
author Rahman, I. N. A.
Manan, F. M. A.
Marzuki, N. H. C.
Mahat, N. A.
Attan, N.
Keyon, A. S. A.
Jamalis, J.
Aboul-Enein, H. Y.
Wahab, R. A.
author_facet Rahman, I. N. A.
Manan, F. M. A.
Marzuki, N. H. C.
Mahat, N. A.
Attan, N.
Keyon, A. S. A.
Jamalis, J.
Aboul-Enein, H. Y.
Wahab, R. A.
author_sort Rahman, I. N. A.
title A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
title_short A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
title_full A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
title_fullStr A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
title_full_unstemmed A statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
title_sort statistical approach for optimizing the high yield green production of the flavor ester butyl butyrate
publisher Penerbit UTM Press
publishDate 2017
url http://eprints.utm.my/id/eprint/76681/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032287415&doi=10.11113%2fjt.v79.10194&partnerID=40&md5=4eb07e55f47a2ca408b6c96176e52734
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