Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold
Tissue engineering has emerged to provide a new medical therapy in helping tissue regrowth and regeneration by employing scaffold as an artificial supporting structure for cellular growth. Many polymers have been utilized in the fabrication of these artificial scaffolds, but there is still a need to...
Saved in:
Main Authors: | , |
---|---|
Format: | Article |
Published: |
Malaysian Society of Analytical Sciences
2017
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/76820/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021133842&doi=10.17576%2fmjas-2017-2103-12&partnerID=40&md5=c89605455df2911216691500245c22eb |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universiti Teknologi Malaysia |
id |
my.utm.76820 |
---|---|
record_format |
eprints |
spelling |
my.utm.768202018-04-30T14:10:33Z http://eprints.utm.my/id/eprint/76820/ Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold Lim, M. M. Sultana, N. TP Chemical technology Tissue engineering has emerged to provide a new medical therapy in helping tissue regrowth and regeneration by employing scaffold as an artificial supporting structure for cellular growth. Many polymers have been utilized in the fabrication of these artificial scaffolds, but there is still a need to fabricate hydrophilic nanofibrous scaffold with appropriate degradation rate. In this study, polycaprolactone (PCL) and polycaprolactone/gelatin (PCL/Ge) 70:30 nanofibrous scaffolds were fabricated using electrospinning technique and compared on in vitro degradation rate to determine a more suitable scaffold for skin tissue engineering application. In vitro degradation was evaluated by morphological changes, water uptake, and chemical bonding until 12 weeks. Result shows that both PCL and PCL/Ge (70:30) nanofibrous scaffolds were degraded after 8th week. However, the degradation rate of PCL nanofibrous scaffold is slower and does not has obvious morphological changes. PCL/Ge (70:30) nanofibrous scaffold with faster degradation rate have the potential for skin tissue engineering application. Malaysian Society of Analytical Sciences 2017 Article PeerReviewed Lim, M. M. and Sultana, N. (2017) Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold. Malaysian Journal of Analytical Sciences, 21 (3). pp. 627-632. ISSN 1394-2506 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021133842&doi=10.17576%2fmjas-2017-2103-12&partnerID=40&md5=c89605455df2911216691500245c22eb DOI:10.17576/mjas-2017-2103-12 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
topic |
TP Chemical technology |
spellingShingle |
TP Chemical technology Lim, M. M. Sultana, N. Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
description |
Tissue engineering has emerged to provide a new medical therapy in helping tissue regrowth and regeneration by employing scaffold as an artificial supporting structure for cellular growth. Many polymers have been utilized in the fabrication of these artificial scaffolds, but there is still a need to fabricate hydrophilic nanofibrous scaffold with appropriate degradation rate. In this study, polycaprolactone (PCL) and polycaprolactone/gelatin (PCL/Ge) 70:30 nanofibrous scaffolds were fabricated using electrospinning technique and compared on in vitro degradation rate to determine a more suitable scaffold for skin tissue engineering application. In vitro degradation was evaluated by morphological changes, water uptake, and chemical bonding until 12 weeks. Result shows that both PCL and PCL/Ge (70:30) nanofibrous scaffolds were degraded after 8th week. However, the degradation rate of PCL nanofibrous scaffold is slower and does not has obvious morphological changes. PCL/Ge (70:30) nanofibrous scaffold with faster degradation rate have the potential for skin tissue engineering application. |
format |
Article |
author |
Lim, M. M. Sultana, N. |
author_facet |
Lim, M. M. Sultana, N. |
author_sort |
Lim, M. M. |
title |
Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
title_short |
Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
title_full |
Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
title_fullStr |
Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
title_full_unstemmed |
Comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
title_sort |
comparison on in vitro degradation of polycaprolactone and polycaprolactone/gelatin nanofibrous scaffold |
publisher |
Malaysian Society of Analytical Sciences |
publishDate |
2017 |
url |
http://eprints.utm.my/id/eprint/76820/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021133842&doi=10.17576%2fmjas-2017-2103-12&partnerID=40&md5=c89605455df2911216691500245c22eb |
_version_ |
1643657418115121152 |