Targeted delivery of bromelain using dual mode nanoparticles: synthesis, physicochemical characterization, in vitro and in vivo evaluation

• Main Authors: Nasiri, Rozita, Almaki, Javad Hamzehalipour, Idris, Ani, Nasiri, Mahtab, Irfan, Muhammad, Majid, Fadzilah Adibah Abdul, Nodeh, Hamid Rashidi, Hasham, Rosnani
• Format: Article
• Language: English
• Published: Royal Society of Chemistry 2017
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/77532/1/RozitaNasiri2017_TargetedDeliveryofbromelainUsingDualMode.pdf; http://eprints.utm.my/id/eprint/77532/; http://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C7RA06389J#!divAbstract
• Institution: Universiti Teknologi Malaysia

The engineering, characterization, and application of dual-functional delivery vehicle "SPIONs-Br-FA" are reported. In this study, a citrate-coated SPIONs (superparamagnetic iron oxide nanoparticles) drug-delivery vehicle was conjugated with Br (bromelain), a phytotherapeutic anticancer ag...