Inhibitory effects of swietenia mahagoni seeds extract on A-glucosidase and A-amylase
This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays. Swietenia mahagoni seeds were extracted by using supercritical carbon dioxide (SC-CO2) extraction at pressures of 20-30 MPa and temperatures of 40-60°C. The oil y...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Materials and Energy Research Center
2018
|
| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/84708/1/LizaMdSalleh2018_InhibitoryEffectsofSwieteniaMahagoniSeed.pdf http://eprints.utm.my/id/eprint/84708/ http://www.ije.ir/article_73249.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Teknologi Malaysia |
| Language: | English |
| Summary: | This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays. Swietenia mahagoni seeds were extracted by using supercritical carbon dioxide (SC-CO2) extraction at pressures of 20-30 MPa and temperatures of 40-60°C. The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays. All data obtained were expressed as mean ± standard deviation for triplicate experiments. One way analysis was used for statistical significance by using statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software. Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent. |
|---|