Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase β activity

Molecular dynamics simulations suggest changes in electrostatic interactions as a potential mechanism through which serine phosphorylation inhibits DNA polymerase β activity

DNA polymerase β is a 39 kDa enzyme that is a major component of Base Excision Repair in human cells. The enzyme comprises two major domains, a 31 kDa domain responsible for the polymerase activity and an 8 kDa domain, which bind ssDNA and has a deoxyribose phosphate (dRP) lyase activity. DNA polyme...

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Bibliographic Details
Main Authors: Homouz, Dirar, Tan, Joyce Kwee Hong, Shamsir, Mohd. Shahir, Moustafa, Ibrahim M., Idriss, Haitham T.
Format: Article
Published: Elsevier Inc. 2018
Subjects:
QH301 Biology
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/85466/
http://dx.doi.org/10.1016/j.jmgm.2018.08.007
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Institution: Universiti Teknologi Malaysia

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http://eprints.utm.my/id/eprint/85466/
http://dx.doi.org/10.1016/j.jmgm.2018.08.007

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