Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch
Transdermal drugs delivery offers many advantages over conventional routes of drug delivery that led to this burgeoning interest in this route in recent years. The aim of this work is to investigate the influence of diclofenac sodium (DS) loaded dual layer PVA patch on physicochemical and mechanical...
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my.utm.916652021-07-14T08:19:23Z http://eprints.utm.my/id/eprint/91665/ Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch Saadon, S. Abdul Razak, S. I. Ismail, A. E. Mat Nayan, N. H. Fakhruddin, K. Q Science (General) Transdermal drugs delivery offers many advantages over conventional routes of drug delivery that led to this burgeoning interest in this route in recent years. The aim of this work is to investigate the influence of diclofenac sodium (DS) loaded dual layer PVA patch on physicochemical and mechanical properties. The influence of DS-loaded dual layer PVA patch was employed and characterized using Scanning Electron Microscopy (SEM) to observe the polymeric interaction between PVA cryogel and electrospun nanofiber, the FTIR were used to study the interaction of DS in dual layer PVA patch and tensile strength were tested to study the mechanical properties of the DS-loaded dual layer PVA patch. The results show the polymer interaction between PVA cryogel and electrospun nanofiber were observed. The DS spectra were found separately from PVA matrix. As for mechanical strength the curves of DS-loaded were decreased as the percentage of DS loading increases. These results shows that the dual layer PVA patch can be used as the carrier for transdermal DS delivery. 2019 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/91665/1/ShafizahSaadon2019_InfluenceofDiclofenacSodium.pdf Saadon, S. and Abdul Razak, S. I. and Ismail, A. E. and Mat Nayan, N. H. and Fakhruddin, K. (2019) Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch. In: 2019 International Conference on Biomedical Engineering, ICoBE 2019, 26-27 Aug 2019, Penang Island, Malaysia. http://dx.doi.org/10.1088/1742-6596/1372/1/012049 |
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Q Science (General) Saadon, S. Abdul Razak, S. I. Ismail, A. E. Mat Nayan, N. H. Fakhruddin, K. Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
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Transdermal drugs delivery offers many advantages over conventional routes of drug delivery that led to this burgeoning interest in this route in recent years. The aim of this work is to investigate the influence of diclofenac sodium (DS) loaded dual layer PVA patch on physicochemical and mechanical properties. The influence of DS-loaded dual layer PVA patch was employed and characterized using Scanning Electron Microscopy (SEM) to observe the polymeric interaction between PVA cryogel and electrospun nanofiber, the FTIR were used to study the interaction of DS in dual layer PVA patch and tensile strength were tested to study the mechanical properties of the DS-loaded dual layer PVA patch. The results show the polymer interaction between PVA cryogel and electrospun nanofiber were observed. The DS spectra were found separately from PVA matrix. As for mechanical strength the curves of DS-loaded were decreased as the percentage of DS loading increases. These results shows that the dual layer PVA patch can be used as the carrier for transdermal DS delivery. |
format |
Conference or Workshop Item |
author |
Saadon, S. Abdul Razak, S. I. Ismail, A. E. Mat Nayan, N. H. Fakhruddin, K. |
author_facet |
Saadon, S. Abdul Razak, S. I. Ismail, A. E. Mat Nayan, N. H. Fakhruddin, K. |
author_sort |
Saadon, S. |
title |
Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
title_short |
Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
title_full |
Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
title_fullStr |
Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
title_full_unstemmed |
Influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
title_sort |
influence of diclofenac sodium loading on physicochemical and mechanical properties of dual layer polyvinyl alcohol transdermal patch |
publishDate |
2019 |
url |
http://eprints.utm.my/id/eprint/91665/1/ShafizahSaadon2019_InfluenceofDiclofenacSodium.pdf http://eprints.utm.my/id/eprint/91665/ http://dx.doi.org/10.1088/1742-6596/1372/1/012049 |
_version_ |
1706956978279940096 |