Biopolymers as potential carrier for effervescent reaction based drug delivery system in gastrointestinal condition

• Main Authors: Muhamad, I. I., Selvakumaran, S., Sis, M. A. M., Pa’e, N., Salehudin, M. H.
• Format: Book Section
• Published: Springer 2020
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/97072/; http://dx.doi.org/10.1007/978-981-10-8405-8_10
• Institution: Universiti Teknologi Malaysia

Biopolymers are naturally occurring materials formed in nature during the life cycles of organisms. Biopolymers include the polysaccharides, carbohydrates and protein such as cellulose, starch, wool, silk, gelatine and collagen. In recent years, biopolymer-based hydrogels become important area of research in pharmaceutical aspects because of their promising properties in drug delivery system. These properties include low toxicity, biodegradability, stability and renewable nature. Numerous studies have been carried out in order to develop carrier from biopolymers with better controlled release properties. This is important to ensure precisely desired concentration of drug or essential nutrient absorption into the blood or tissue could be achieved. Among other different approaches, floating system is one of the most convenient, economical, and effective drug delivery system. Floating delivery system could potentially achieve longer retention time of carrier with capsulated bioactive drug or functional nutrients in the gastrointestinal tract. The floating behaviour of carrier could be induced by effervescent reactions. Effervescent reaction occurs between acidic gastric content and pore forming agent such as carbonates or bicarbonates salts incorporated into the carrier. This chapter discusses some of the use of biopolymers in drug delivery systems for effervescent reaction in gastrointestinal tract.