Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study

The water-drinking test (WDT) is a provocative test used in glaucoma research to assess the effects of elevated intraocular pressure (IOP). Defective autoregulation due to changes in perfusion pressure may play a role in the pathophysiology of several ocular diseases. This study aims to examine the...

Full description

Saved in:
Bibliographic Details
Main Authors: Bhatti, M.S., Tang, T.B., Laude, A.
Format: Article
Published: Public Library of Science 2017
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025164854&doi=10.1371%2fjournal.pone.0181512&partnerID=40&md5=72ade22249c588c53f41338d718d2df8
http://eprints.utp.edu.my/19460/
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Universiti Teknologi Petronas
id my.utp.eprints.19460
record_format eprints
spelling my.utp.eprints.194602018-04-20T05:58:35Z Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study Bhatti, M.S. Tang, T.B. Laude, A. The water-drinking test (WDT) is a provocative test used in glaucoma research to assess the effects of elevated intraocular pressure (IOP). Defective autoregulation due to changes in perfusion pressure may play a role in the pathophysiology of several ocular diseases. This study aims to examine the effects of WDT on ocular blood flow (in the form of pulse waveform parameters obtained using laser speckle flowgraphy) to gain insight into the physiology of ocular blood flow and its autoregulation in healthy individuals. Changes in pulse waveform parameters of mean blur rate (MBR) in the entire optic nerve head (ONH), the vasculature of the ONH, the tissue area of the ONH, and the avascular tissue area located outside of the ONH were monitored over time. Significant increases in the falling rate of MBR over the entire ONH and its tissue area and decreases in blowout time (BOT) of the tissue area were observed only at 10 minutes after water intake. Significant increases in the skew of the waveform and the falling rate were observed in the vasculature of the ONH at 40 and 50 minutes after water intake, respectively. In the avascular region of the choroid, the average MBR increased significantly up to 30 minutes after water intake. Furthermore, the rising rate in this region increased significantly at 20 and 40 minutes, and the falling rate and acceleration-time index were both significantly increased at 40 minutes after water intake. Our results indicate the presence of effective autoregulation of blood flow at the ONH after WDT. However, in the choroidal region, outside of the ONH, effective autoregulation was not observed until 30 minutes after water intake in healthy study participants. These pulse waveform parameters could potentially be used in the diagnosis and/or monitoring of patients with glaucoma. © 2017 Bhatti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Public Library of Science 2017 Article PeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025164854&doi=10.1371%2fjournal.pone.0181512&partnerID=40&md5=72ade22249c588c53f41338d718d2df8 Bhatti, M.S. and Tang, T.B. and Laude, A. (2017) Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study. PLoS ONE, 12 (7). http://eprints.utp.edu.my/19460/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description The water-drinking test (WDT) is a provocative test used in glaucoma research to assess the effects of elevated intraocular pressure (IOP). Defective autoregulation due to changes in perfusion pressure may play a role in the pathophysiology of several ocular diseases. This study aims to examine the effects of WDT on ocular blood flow (in the form of pulse waveform parameters obtained using laser speckle flowgraphy) to gain insight into the physiology of ocular blood flow and its autoregulation in healthy individuals. Changes in pulse waveform parameters of mean blur rate (MBR) in the entire optic nerve head (ONH), the vasculature of the ONH, the tissue area of the ONH, and the avascular tissue area located outside of the ONH were monitored over time. Significant increases in the falling rate of MBR over the entire ONH and its tissue area and decreases in blowout time (BOT) of the tissue area were observed only at 10 minutes after water intake. Significant increases in the skew of the waveform and the falling rate were observed in the vasculature of the ONH at 40 and 50 minutes after water intake, respectively. In the avascular region of the choroid, the average MBR increased significantly up to 30 minutes after water intake. Furthermore, the rising rate in this region increased significantly at 20 and 40 minutes, and the falling rate and acceleration-time index were both significantly increased at 40 minutes after water intake. Our results indicate the presence of effective autoregulation of blood flow at the ONH after WDT. However, in the choroidal region, outside of the ONH, effective autoregulation was not observed until 30 minutes after water intake in healthy study participants. These pulse waveform parameters could potentially be used in the diagnosis and/or monitoring of patients with glaucoma. © 2017 Bhatti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
format Article
author Bhatti, M.S.
Tang, T.B.
Laude, A.
spellingShingle Bhatti, M.S.
Tang, T.B.
Laude, A.
Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
author_facet Bhatti, M.S.
Tang, T.B.
Laude, A.
author_sort Bhatti, M.S.
title Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
title_short Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
title_full Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
title_fullStr Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
title_full_unstemmed Effects of water drinking test on ocular blood flow waveform parameters: A laser speckle flowgraphy study
title_sort effects of water drinking test on ocular blood flow waveform parameters: a laser speckle flowgraphy study
publisher Public Library of Science
publishDate 2017
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025164854&doi=10.1371%2fjournal.pone.0181512&partnerID=40&md5=72ade22249c588c53f41338d718d2df8
http://eprints.utp.edu.my/19460/
_version_ 1738656073239232512