Determination of Three Endocrine Disruptors in Water Samples by Ultrasound-Assisted Salt-Induced Liquid-Liquid Microextraction (UA-SI-LLME) and High-Performance Liquid Chromatography�Diode Array Detection (HPLC-DAD)

• Main Authors: Rozaini, M.N.H., Saad, B., Yahaya, N., Lim, J.W., Mohd Aris, M.N., Ramachandran, M.R.
• Format: Article
• Published: Taylor and Francis Ltd. 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106048229&doi=10.1080%2f00032719.2021.1919691&partnerID=40&md5=99bca6089af6dce8d4b978af059f1588; http://eprints.utp.edu.my/28828/
• Institution: Universiti Teknologi Petronas

Endocrine-disrupting compounds are routinely detected in environmental water. In this study, a simple and rapid sample preparation method based on ultrasound-assisted salt-induced liquid-liquid microextraction (UA-SI-LLME) followed by high performance liquid chromatography�diode array detection (HPLC-DAD) was developed for the determination of triclosan, triclocarban and methyl-triclosan in water. Parameters that affect the extraction efficiency�such as type and mass of salt, type and volume of extraction solvent, extraction time, sample pH and sample volume�were studied. Under the optimized conditions, the method demonstrated linearity from 0.18 to 1000 µg L�1 with coefficients of determination R2 � 0.9899, limits of detection from 0.05 to 0.2 µg L�1, and good recoveries (> 70) with relative standard deviations < 10. The method was applied for the determination of triclosan, triclocarban, and methyl-triclosan in swimming pool, lake, and wastewater. The greenness of the method was quantified using the Analytical Eco-Scale Index. © 2022 Taylor & Francis Group, LLC.