Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors

• Main Authors: V. Kemami Wangun, Hilaire, Hartl, Albert, Trinh Tam, Kiet, Hertweck, Christian
• Format: Article
• Language: English
• Published: Organic & Biomolecular Chemistry 2016
• Subjects: cyclooxygenases (COX); xanthine oxidase (OX); new anti- inflammatory; anti- arthritic therapeutics; mushroom Inonotus
• Online Access: http://repository.vnu.edu.vn/handle/VNU_123/10561
• Institution: Vietnam National University, Hanoi

Arthritis is a general term for severe inflammatory processes in joints or joint tissue. Nonsteroidal anti-inflammatory drugs , such as diclofenac and indomethacin, have emerged the most commonly used anti- inflammatory agents for the therapy of rheumatoid arthritis. Many of these drugs target cyclo...