Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis
Background:Utility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health...
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oai:112.137.131.14:VNU_123-114322017-04-05T14:27:40Z Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis Nguyen, Hoang Long Quality of life Utility HIV Longitudinal meta-analysis Systematic review Background:Utility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by disease stages, and investigate changes in their health utility over the course of antiretroviral treatment. Methods:We searched PubMed/Medline, Cochrane Database of Systematic Review, NHS Economic Evaluation Database and Web of Science for English-language peer-reviewed papers published during 2000–2013. We selected 49 studies that used 3 direct and 6 indirect preference based instruments to make a total of 218 utility measurements. Random effect models with robust estimation of standard errors and multivariate fractional polynomial regression were used to obtain the pooled estimates of utility and model their trends. Results:Reliability of direct-preference measures tended to be lower than other types of measures. Utility elicited by two of the indirect preference measures - SF-6D (0.171) and EQ-5D (0.114), and that of Time-Trade off (TTO) (0.151) was significantly different than utility elicited by Standard Gamble (SG). Compared to asymptomatic HIV patients, symptomatic and AIDS patients reported a decrement of 0.025 (p&#×2009;=&#×2009;0.40) and 0.176 (p&#×2009;=&#×2009;0.001) in utility scores, adjusting for method of assessment. In longitudinal studies, the pooled health utility of HIV/AIDS patients significantly decreased in the first 3 months of treatment, and rapidly increased afterwards. Magnitude of change varied depending on the method of assessment and length of antiretroviral treatment. Conclusion:The study provides an accumulation of evidence on measurement properties of health utility estimates that can help inform the selection of instruments for future studies. The pooled estimates of health utilities and their trends are useful in economic evaluation and policy modelling of HIV/AIDS treatment strategies 2016-05-30T12:20:14Z 2016-05-30T12:20:14Z 2015 Article 1472-6963 http://repository.vnu.edu.vn/handle/VNU_123/11432 en application/pdf BioMed Central |
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Quality of life Utility HIV Longitudinal meta-analysis Systematic review Nguyen, Hoang Long Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
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Background:Utility estimates are important health outcomes for economic evaluation of care and treatment
interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements
to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by
disease stages, and investigate changes in their health utility over the course of antiretroviral treatment.
Methods:We searched PubMed/Medline, Cochrane Database of Systematic Review, NHS Economic Evaluation
Database and Web of Science for English-language peer-reviewed papers published during 2000–2013. We selected 49
studies that used 3 direct and 6 indirect preference based instruments to make a total of 218 utility measurements.
Random effect models with robust estimation of standard errors and multivariate fractional polynomial regression were
used to obtain the pooled estimates of utility and model their trends.
Results:Reliability of direct-preference measures tended to be lower than other types of measures. Utility elicited by
two of the indirect preference measures - SF-6D (0.171) and EQ-5D (0.114), and that of Time-Trade off (TTO) (0.151) was
significantly different than utility elicited by Standard Gamble (SG). Compared to asymptomatic HIV patients, symptomatic
and AIDS patients reported a decrement of 0.025 (p&#×2009;=&#×2009;0.40) and 0.176 (p&#×2009;=&#×2009;0.001) in
utility scores, adjusting for method of assessment. In longitudinal studies, the pooled health utility of HIV/AIDS
patients significantly decreased in the first 3 months of treatment, and rapidly increased afterwards. Magnitude of
change varied depending on the method of assessment and length of antiretroviral treatment.
Conclusion:The study provides an accumulation of evidence on measurement properties of health utility estimates
that can help inform the selection of instruments for future studies. The pooled estimates of health utilities and their
trends are useful in economic evaluation and policy modelling of HIV/AIDS treatment strategies |
format |
Article |
author |
Nguyen, Hoang Long |
author_facet |
Nguyen, Hoang Long |
author_sort |
Nguyen, Hoang Long |
title |
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
title_short |
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
title_full |
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
title_fullStr |
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
title_full_unstemmed |
Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis |
title_sort |
longitudinal and cross sectional assessments of health utility in adults with hiv/aids: a systematic review and meta-analysis |
publisher |
BioMed Central |
publishDate |
2016 |
url |
http://repository.vnu.edu.vn/handle/VNU_123/11432 |
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1680964796824944640 |