Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa
Recently, the resources of medicinal plants have been exhausting. The root ofAngelica acutilobais one of the most important ingredients in Japanese Kampo medicine for the treatment of gynecological diseases. In our search for alternative medicinal plant resources of the root ofA. acutiloba, we fou...
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oai:112.137.131.14:VNU_123-114462017-04-05T14:27:40Z Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa Nguyen, Huu Tung Angelica acutiloba Aerial part Z-ligustilide Tokiaerialide Anti-inflammation Macrophages Recently, the resources of medicinal plants have been exhausting. The root ofAngelica acutilobais one of the most important ingredients in Japanese Kampo medicine for the treatment of gynecological diseases. In our search for alternative medicinal plant resources of the root ofA. acutiloba, we found that its aerial part has the anti-inflammatory potency as well as the root. Phytochemical investigation of the aerial part resulted in the isolation of four compounds including a new dimeric phthalide, namely tokiaerialide (2), along with Z-ligustilide (1), falcarindiol (3), and bergaptol (4). Next, we investigated thein vitro anti-inflammatory activity of 1–4 in lipopolysaccharide-stimulated RAW264 macrophages. Among the isolated compounds, 1 exhibited the most potent inhibition against lipopolysaccharide-induced production of prostaglandin E2,nitricoxide,and pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α). Compounds 3 and 4 also inhibited all inflammatory mediators, but their inhibitory abilities were weaker than those of 1. Furthermore, 1, 3, and 4 strongly also induced heme oxygenase-1. These results suggest that 1, 3, and 4 potentially exert anti-inflammatory activity, and the aerial part ofA. acutilobamay be considered to be a useful medicinal resource for inflammatory diseases. 2016-05-30T13:20:08Z 2016-05-30T13:20:08Z 2015 Article 1097-0037 http://repository.vnu.edu.vn/handle/VNU_123/11446 en application/pdf Wiley |
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Angelica acutiloba Aerial part Z-ligustilide Tokiaerialide Anti-inflammation Macrophages |
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Angelica acutiloba Aerial part Z-ligustilide Tokiaerialide Anti-inflammation Macrophages Nguyen, Huu Tung Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
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Recently, the resources of medicinal plants have been exhausting. The root ofAngelica acutilobais one of the
most important ingredients in Japanese Kampo medicine for the treatment of gynecological diseases. In our
search for alternative medicinal plant resources of the root ofA. acutiloba, we found that its aerial part has
the anti-inflammatory potency as well as the root. Phytochemical investigation of the aerial part resulted in
the isolation of four compounds including a new dimeric phthalide, namely tokiaerialide (2), along with
Z-ligustilide (1), falcarindiol (3), and bergaptol (4). Next, we investigated thein vitro anti-inflammatory activity
of 1–4 in lipopolysaccharide-stimulated RAW264 macrophages. Among the isolated compounds, 1 exhibited the
most potent inhibition against lipopolysaccharide-induced production of prostaglandin E2,nitricoxide,and
pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor-α). Compounds 3 and 4 also inhibited
all inflammatory mediators, but their inhibitory abilities were weaker than those of 1. Furthermore, 1, 3, and
4 strongly also induced heme oxygenase-1. These results suggest that 1, 3, and 4 potentially exert
anti-inflammatory activity, and the aerial part ofA. acutilobamay be considered to be a useful medicinal
resource for inflammatory diseases. |
format |
Article |
author |
Nguyen, Huu Tung |
author_facet |
Nguyen, Huu Tung |
author_sort |
Nguyen, Huu Tung |
title |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
title_short |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
title_full |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
title_fullStr |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
title_full_unstemmed |
Anti-inflammatory Activity of Constituents Isolated from Aerial Part ofAngelica acutilobaKitagawa |
title_sort |
anti-inflammatory activity of constituents isolated from aerial part ofangelica acutilobakitagawa |
publisher |
Wiley |
publishDate |
2016 |
url |
http://repository.vnu.edu.vn/handle/VNU_123/11446 |
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1680967788284346368 |