Determination of the absolute configuration of the novel anti-trypanosomal iridoid molucidin isolated fromMorinda lucida by X-ray analysis

• Main Authors: Nguyen, Huu Tung, Karasawa, Satoru, Yoza, Kenji, Morinaga, Osamu, Suzuki, Mitsuko, Kwofie, Kofi D., Amoa-Bosompem, Michael, Boakye, Daniel A., Ayi, Irene, Adegle, Richard, Sakyiamah, Maxwell, Ayertey, Frederick, Aboagye, Frederic, Appiah, Alfred A., Owusu, Kofi B.-A., Tuffour, Isaac, Atchoglo, Philip, Frempong, Kwadwo K., Anyan, William K., Appiah-Opong, Regina, Nyarko, Alexander K., Yamashita, Taizo, Yamaguchi, Yasuchika, Edoh, Dominic, Koram, Kwadwo, Yamaoka, Shoji, Ohta, Nobuo, Shoyama, Yukihiro
• Format: Article
• Language: English
• Published: Tetrahedron Letters 2016
• Subjects: Morinda lucida; Rubiaceae; Molucidin; Anti-trypanosomal activity; X-ray analysis; Absolute configuration
• Online Access: http://repository.vnu.edu.vn/handle/VNU_123/11450
• Institution: Vietnam National University, Hanoi

The strong anti-trypanosomal active compound, molucidin, contains a spirolactone tetracyclic iridoid skeleton and is isolated fromMorinda lucidaas an enantiomer of oruwacin, which is isolated from the same plant. To confirm the absolute configuration of molucidin, we prepared single crystals of mo...