Isolated Compounds and Cardiotonic Effect on the Isolated Rabbit Heart of Methanolic Flower Extract of Nerium oleander L.
Nerium oleander L. is an evergreen shrub in the dogbane family Apocynaceae and planted throughout the tropical region. It has cardiotonic, antioxidant, anti-inflammatory and anticancer activities.Nerium oleanderL. has high amount of cardiac glycoside and flavonoids compounds. From methanol extrac...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Journal of Phytochemistry
2016
|
| Subjects: | |
| Online Access: | http://repository.vnu.edu.vn/handle/VNU_123/11501 https://scialert.net/abstract/?doi=rjphyto.2016.21.29 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Vietnam National University, Hanoi |
| Language: | English |
| Summary: | Nerium oleander L. is an evergreen shrub in the dogbane family Apocynaceae and planted
throughout the tropical region. It has cardiotonic, antioxidant, anti-inflammatory and anticancer
activities.Nerium oleanderL. has high amount of cardiac glycoside and flavonoids compounds.
From methanol extract of flowers of Nerium oleanderL. grown in vietnam, it has been isolated four
compounds. Their structures were identified as (1) D
16
-Dehydroadynerigenin, (2) D
16
-Digitoxigenin,
(3) Quercetin and (4) Kaempferol on the basis of spectroscopic data and by comparing their
physicochemical and spectral data with those published studies. The effect of fraction HF2, which
containing compound 1 and 2 on heart function was examined, revealing potent positive inotropic
effect on isolated rabbit heart by increasing the contractility and coronary flow heart but does not
alter heart rate |
|---|