Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling

• المؤلف الرئيسي: Le, Thi Thu Huong
• التنسيق: مقال
• اللغة: English
• منشور في: Springer 2016
• الموضوعات: ADME modeling; Caco-2 cell permeability; Biopharmaceutics classification system; Support vector machine; Cost-sensitive learning; Resampling technique
• الوصول للمادة أونلاين: http://repository.vnu.edu.vn/handle/VNU_123/11505

In many absorption, distribution, metabolism, and excretion (ADME) modeling problems, imbalanced data could negatively affect classification performance of machine learning algorithms. Solutions for handling imbal-anced dataset have been proposed, but their application for ADME modeling tasks is...